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Located four kilometers from the center of Florence, the "Amerigo Vespucci" Airport occupies an area of approximately 115 hectares between Castello and the Plain of Sesto Fiorentino. The area, to the north-west of Florence, lies between the "Firenze Nord" exit from the superhighway and Florence's industrial area near Prato.

The airport can be reached from the center of Florence, driving the whole length of Viale Guidoni up to the road leading to the "Firenze Nord/Firenze Mare" superhighway (A1 and A11). The airport also has good connections to the center of the city, which can be reached in about fifteen minutes by taxi, and about twenty minutes by the Sita/Ataf service "Fly by Bus" between the airport and Santa Maria Novella railway station. But being in the heart of Florence also means, even more, being in the heart of Tuscany. In fact the airport can be easily reached from Prato (8 km), Pistoia (24 km), Montecatini (36 km), Lucca (65 km), Siena (68 km), Arezzo (77 km), Pisa (86 km), Carrara and Massa (117 km), Grosseto (143 km), as well as from the sea and its ports: Livorno (115 km) and Piombino (170 km).